Objective: To explore the clinical effect of the method of Liangxuesanyu stasis on the patients with severe pneumonia and its mechanism. Methods: From March 2018 to October 2019, 60 patients who met the diagnosis criteria of severe pneumonia were selected from the Department of critical medicine, Affiliated Hospital of Nanjing University of traditional Chinese medicine. They were divided into 30 Chinese medicine groups and 30 control groups according to the random number table method. Patients in both groups were given conventional Western medicine treatment such as anti-infection, phlegm elimination, nutritional support, and respiratory support. Patients in the Chinese medicine group were added Liangxuesanyu Granules (shuiniujiao 20g, zhidahuang 10g, taoren 10g, shengdi 20g, mudanpi 10g, chishao 15g, danshen 20g), Wash with warm water to 200ml, and take 100ml orally or nasally each morning and evening. The course of treatment is 14 days. The differences in respiratory function, inflammatory response, and mortality at 28 days were compared between the two groups of patients before and on the 7th and 14th days after treatment. Results: The oxygenation index (PO2/FiO2) of the Chinese medicine group was significantly higher than that of the control group at the 7th day after treatment (P<0.01). The tracheal intubation rate, Murray score, WBC, TNF-α, and PCT were all lower than those of the control group. (P<0.05); On the 14th day after treatment, the oxygenation index (PO2/FiO2) of the Chinese medicine group was higher than the control group (P <0.05), the TNF-αwas lower than the control group (P<0.05), and the Murray score was significantly lower than the control group (P<0.01); The mechanical ventilation time of the Chinese medicine group was lower than that of the control group (P0.05). Conclusion: The intervention of Liangxuesanyu method in the treatment of severe pneumonia can effectively reduce the inflammatory response of patients, improve the oxygenation level and reduce the time of mechanical ventilation.