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目的观察优化头孢他啶治疗方案对心力衰竭合并下呼吸道感染的临床疗效。方法 63例以头孢他啶每12h 1g静脉输注为对照组。实验组62例患者给予头孢他啶1g快速输注,后2g于3h内给予;共7d。结果实验组和对照组的有效率分别为95.2%及93.6%(P>0.05);实验组细菌清除率(58.3%)稍高于对照组(53.1%,P>0.05);对照组复诊次数明显减少。结论头孢他啶根据药效/药代学理论优化的治疗方案疗效好,值得推广。
Objective To observe the clinical efficacy of optimized ceftazidime regimen in patients with heart failure and lower respiratory tract infection. Methods 63 cases of ceftazidime every 12h 1g intravenous infusion as the control group. In the experimental group, 62 patients were given 1 g ceftazidime fast infusion, and 2 g was given within 3 h after a total of 7 days. Results The effective rates of the experimental group and the control group were 95.2% and 93.6%, respectively (P> 0.05). The bacterial clearance rate in the experimental group (58.3%) was slightly higher than that in the control group (53.1%, P> 0.05) cut back. Conclusion Ceftazidime has a good curative effect based on the pharmacodynamic / pharmacokinetic theory and is worth promoting.