论文部分内容阅读
潘生丁的药代动力学 离体试验表明,潘生丁1.75μg/ml能降低血小板聚集和血小板因子4的释放至正常或正常以下。一次口服100mg潘生丁45例的血药浓度峰值为1.2-1.9μg/ml,最低浓度为0.1-0.8μg/ml;但口服与静脉给药后的血药浓度在病人间有较大差异.迄今,尚缺少临床研究潘生丁血药浓度的具体资料,潘生丁血药浓度与疗效之间的关系因此尚未确定.
Pharmacokinetic ex vivo trials of dipyridamole showed that dipyridamole 1.75 μg / ml reduced platelet aggregation and release of platelet factor 4 below normal or normal levels. The oral administration of 100 mg dipyridamole peak plasma concentration of 45 cases of 1.2-1.9μg / ml, the lowest concentration of 0.1-0.8μg / ml; but after oral administration and intravenous administration of blood drug concentration in patients there is a big difference so far, The lack of specific clinical data on the concentration of dipyridamole blood, dipyridamyl plasma concentration and the relationship between efficacy has not yet been determined.