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棉酚是一种颇有希望的男子节育药。临床试用表明,其效果良好,然而可偶致低血钾性肌无力症,后者是否与棉酚有关,尚无定论。虽离体实验表明,棉酚可使心肌失钾;但在整体动物,一般均认为,棉酚不影响钾代谢。 我们在常规、低钾及低镁饲养大鼠,观察了不同剂量棉酚对细胞内、外离子(主要是钾、镁)、可交换钾、某些肾功能及其它一些方面的影响,结果表明: 在低钾饲养大鼠,大剂量棉酚可引起骨骼肌胞内钾、镁离子浓度普遍下降;在常规饲养动物,同量棉酚只引起个别肌肉胞内钾离子浓度下降。据此,可以认为,棉酚可影响钾代谢,而低钾摄入可能为棉酚所致钾代谢障碍的一个协同因子。 在低钾饲养大鼠,小剂量棉酚可使半数肌肉的胞内镁离子浓度下降;大剂量则使所有受测肌肉的胞内钾、镁离子浓度下降,但此时血清钾不降,尿浓缩功能保持良好。凡此均提示,棉酚所致钾代谢障碍可能与镁代谢紊乱有关。 大剂量棉酚可引起骨骼肌的萎缩性改变,表现在体重和肌重下降,尿中肌酐系数下降以及以身长为尺度的可交换钾量减少。
Gossypol is a promising male birth control drug. Clinical trials show that its effect is good, however, can be occasionally hypokalemic myasthenia, the latter is related with gossypol, is not conclusive. Although in vitro experiments show that gossypol can make the myocardium lose potassium; but in the whole animal, it is generally believed that gossypol does not affect potassium metabolism. We observed the effects of different dosages of gossypol on intracellular and extracellular ions (mainly potassium and magnesium), exchangeable potassium, some renal functions and some other aspects in rats fed conventional, low potassium and low magnesium. The results showed that : In low-potassium fed rats, high-dose gossypol can cause a general decline in intracellular potassium and magnesium ion concentrations in skeletal muscle. In conventional feeding animals, same amount of gossypol causes only a decrease in intracellular potassium concentration in individual muscle cells. Based on this, it can be considered that gossypol can affect potassium metabolism, while low potassium intake may be a synergistic factor for gossypol-induced potassium metabolism disorder. In low-K fed rats, low doses of gossypol reduced the intracellular Mg2 + concentration in half of the muscles. In high doses, the intracellular potassium and Mg2 + concentrations in all tested muscles decreased, but serum K did not decrease and urine Concentration function to maintain good. All this suggests that gossypol-induced potassium metabolism disorders may be related to magnesium metabolic disorders. High doses of gossypol can cause atrophic changes in skeletal muscle, manifested in weight and weight loss, decreased urinary creatinine factor and the length of the scale of exchangeable potassium decreased.