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潘生丁有抑制血小板活性的作用.血小板中磷酸二酯酶被抑制,激发内源性前列腺素I_2及抑制红细胞对腺甙的再摄入,因而提高血浆中的腺甙(腺甙是很强的血小板抑制剂).虽然潘生丁广泛用于临床但尚未在体内证实潘生丁能抑制动脉血管内急性血小板血栓形成.研究证实急性血小板血栓形成的发生伴随间歇性栓塞.人为使犬患冠状动脉狭窄症,从而引起冠状动脉血流周期性的减少,同时证明冠状动脉血流周期性减少能被多种血小板抑制剂所消除.10只人工患冠状动脉狭窄症的开胸犬见到冠状动脉血流周期性地减少为12±4次/h.缓慢地给犬静脉注入潘生丁(2.0
Dipyridamole inhibition of platelet activity in platelet phosphodiesterase is inhibited, stimulate endogenous prostaglandin I_2 and inhibition of red blood cell adenosine re-intake, thereby increasing plasma adenosine (adenosine is a very strong platelet Inhibitor.) Although dipyridamole is widely used in clinical trials, dipyridamole has been shown not to inhibit acute thrombocytopenia in the arteries in vivo, confirming the occurrence of acute thrombotic thrombosis associated with intermittent embolism. Periodic reductions in coronary blood flow and periodic decreases in coronary blood flow were shown to be abolished by a variety of platelet inhibitors.10 Coronary flow was periodically reduced in 10 open-chest dogs with artificial coronary artery stenosis 12 ± 4 times / h. Dogs were slowly given dipyridamole (2.0