一般认为,消化性溃疡的发病与胃肠粘膜损害因素(胃酸、胃蛋白酶)增强和(或)胃肠粘膜自身防御因素(粘膜屏障、粘液)减弱有关。晚近,关于消化性溃疡发病机理的热门课题为幽门螺旋菌(CP)感染。大量研究证实 CP 感染与消化性溃疡密切相关。自70年代初组胺 H_2受体拮抗剂问世以来,针对消化性溃疡发病过程中胃酸过多这个主要损害因素的治疗有了突破性的进展。十多年来,H_2受体拮抗剂支配着消 It is generally believed that the incidence of peptic ulcer and gastrointestinal mucosal damage factors (gastric acid, pepsin) and (or) gastrointestinal mucosal defense factors (mucosal barrier, mucus) decreased. Recently, a hot topic on the pathogenesis of peptic ulcer disease is Helicobacter pylori (CP) infection. Numerous studies have confirmed that CP infection is closely related to peptic ulcer. Since the advent of histamine H 2 receptor antagonists in the early 1970s, breakthroughs have been made in the treatment of the major damaging factor of hyperacidity in the pathogenesis of peptic ulcer disease. For more than a decade, H 2 receptor antagonists dominate