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维库溴铵与苯磺阿曲库铵应用于肝肾功能正常者33例、末期肾衰病人26例、阻塞性黄疸病人20例。静注维库溴铵与苯磺阿曲库铵初剂量分别为0.1mg/kg和0.5mg/kg,每次追加剂量分别为0.05mg/kg和0.25mg/kg,术中用4个成串刺激(TOF)监测肌松程度。应用2药于肾衰组,除起效时间较其他2组明显缩短外,其他参数无差异,前者用于阻黄病人时,TOF在恢复过程中第4(T_4)与第1(T_1)个刺激反应强度之比(RTOF)0.25和恢复指数均有明显延长,提示有积蓄作用,使用时应慎重。
Vecuronium and benzenesulfonamide were used in 33 patients with normal liver and kidney function, 26 patients with end-stage renal failure, and 20 patients with obstructive jaundice. Intravenous vecuronium and benzene sulfatracurium initial dose of 0.1mg / kg and 0.5mg / kg, respectively, each additional dose of 0.05mg / kg and 0.25mg / kg, intraoperative use of a string of 4 Tolerance (TOF) monitoring of muscle relaxation. Application of 2 drugs in renal failure group, in addition to the onset time was significantly shorter than the other two groups, the other parameters were no difference, the former for the prevention of yellow patients, TOF in the recovery process 4 (T_4) and 1 (T_1) Reactivity intensity ratio (RTOF) 0.25 and recovery index were significantly prolonged, suggesting a savings effect, should be used carefully.