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以α-氰基乙酸甲酯为起始原料,经与二硫化碳、碘甲烷反应先得到α-氰基二硫缩烯酮1,1与苯乙酮2反应得2H-吡喃-2-酮-3-腈化物3,碱诱导下3再与丙二腈经环转化得到多取代邻氨基芳香腈4,4与酮5在氢氧化钠催化下环化得到多取代喹唑啉酮目标物6.这组连续转化合成多取代喹唑啉酮的反应具有原料简便、反应温和等优点.
Methyl α-cyanoacetate as a starting material, with carbon disulfide, methyl iodide reaction first obtained α-cyano dithianketene 1,1 and acetophenone 2 2H-pyran-2-one - 3-nitrile 3, under the induction of base 3 and then with the conversion of malononitrile obtained by ring-ring poly-substituted anthranilic aromatic nitriles 4,4 and ketone 5 under sodium hydroxide catalyst cyclization to give multi-substituted quinazolinone target 6. This group of continuous conversion synthesis of multi-substituted quinazolinone reaction has the advantages of simple raw materials, mild reaction and so on.