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目的探讨左乙拉西坦单药治疗癫痫的效果及其对认知功能的影响。方法按治疗方法的不同将80例患儿随机分为研究组和对照组,研究组患儿服用单药左乙拉西坦治疗,对照组患儿服用丙戊酸钠治疗,两组患儿治疗时间均为24周。观察治疗前后患儿的发病频率及治疗后的不良反应,并进行韦氏智力量表测试。结果 1与对照组相比,研究组患儿的总体有效率明显升高(P<0.05);2认知能力的比较中,与治疗前相比,研究组患儿言语(VIQ)、操作(PIQ)及总智商(FIQ)、分类、领悟、背数项目在治疗后均有明显提高,而对照组中治疗后的各个项目均无明显变化;3与治疗后对照组相比,治疗后研究组患儿IQ、PIQ、FIQ、分类、领悟、背数项目有明显提高(P<0.05)。结论左乙拉西坦单药治疗癫痫的疗效确切,能够有效的降低癫痫的发作次数,改善患者认知功能。
Objective To investigate the effect of levetiracetam monotherapy on epilepsy and its effect on cognitive function. Methods According to the different treatment methods, 80 cases were randomly divided into study group and control group. The study group took single-agent levetiracetam, while the control group took sodium valproate. Two groups of children received treatment The time is 24 weeks. Observe the incidence of children before and after treatment frequency and adverse reactions after treatment, and Wechsler Intelligence Scale test. Results 1 Compared with the control group, the overall effective rate of the study group was significantly increased (P <0.05) .2 Comparison of cognitive ability, compared with before treatment, the study group children’s speech (VIQ), operation ( PIQ), total intelligence (FIQ), classification, comprehension and back count significantly increased after treatment, while no significant changes were found in the control group after treatment. 3 Compared with the control group after treatment, after treatment The scores of IQ, PIQ, FIQ, classification, comprehension and back count of children in the group were significantly increased (P <0.05). Conclusion Levetiracetam monotherapy for the treatment of epilepsy exact effect, can effectively reduce the frequency of epileptic seizures, improve cognitive function in patients.