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NK细胞识别、杀伤靶细胞有赖于活化或抑制性受体与多种配体问的相互作用。这些受体可分为两类不同的蛋白 家族:KLRs和带有免疫球蛋白样结构域的受体,均有抑制性和活化性成员。抑制性受体胞浆尾部含有ITIMs;活化性受 体缺乏ITIMs,但在跨膜区有一个正电氨基酸并与含有ITAM的接头分子相关联。SHP-1与磷酸化的ITIMs关联介导抑 制NK细胞的细胞毒性。本研究报道了克隆的一个新的NK细胞受体KLRE1。初步的实验结果提示KLRE1能抑制NK 细胞的细胞毒性。
NK cells recognize and kill target cells depending on the interaction between activated or inhibitory receptors and various ligands. These receptors fall into two distinct families of proteins: KLRs and receptors with immunoglobulin-like domains, both inhibitory and activating members. The inhibitory receptor cytoplasmic tail contains ITIMs; the activated receptor lacks ITIMs but has a positive amino acid in the transmembrane region and is associated with linker molecules containing ITAM. The association of SHP-1 with phosphorylated ITIMs mediates the cytotoxicity of NK cells. This study reports the cloning of a new NK cell receptor, KLRE1. Preliminary results suggest that KLRE1 can inhibit the cytotoxicity of NK cells.