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目的 探讨我国男性系统性红斑狼疮 (SLE)的临床特点。方法 对 76例男性SLE患者作临床分析 ,并与女性SLE匹配对比。结果 与女性相比 ,男性SLE患者的发病年龄、初发症状、临床表现及实验室检查的免疫学异常基本相似 ,但其面部蝶形红斑、脱发、关节炎的发生率较低 (P <0 .0 5 ) ,而中枢神经系统损害、肾脏损害、血小板减少发生率高 (P <0 .0 5 ) ,发病后 5a内的死亡率较高 (P <0 .0 5 )。结论 男性SLE不但预后较差 ,且有其自身的临床特点 ,诊断和治疗时都应注意。
Objective To investigate the clinical features of male systemic lupus erythematosus (SLE) in China. Methods 76 cases of male SLE patients were analyzed clinically and matched with female SLE. Results Compared with women, the onset age, initial symptoms, clinical manifestations and laboratory immunological abnormalities in SLE patients were similar, but the incidence of facial butterfly erythema, alopecia, and arthritis was lower (P <0 (P <0.05). The incidence of central nervous system damage, renal damage and thrombocytopenia was high (P <0.05), and the mortality rate within 5 years after onset was higher (P <0.05). Conclusion Male SLE not only has a poor prognosis, but also has its own clinical features, which should be paid attention to in diagnosis and treatment.