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目的初步探讨人类白细胞抗原G(human leukocyte antigen G,HLA-G)*0105N基因(rs 41557518)多态性与新疆哈萨克族(哈族)食管癌遗传易感性的关系。方法采用病例-对照研究方法 ,调查新疆地区哈族食管癌患者132例(病例组)和健康对照254例(对照组),应用PCR-RFLP方法检测HLA-G*0105 N(rs 41557518)多态性。结果基因型C/-、C/C-、/-,在病例组中的频率分别为8.33%、91.67%、0%,在对照组中的频率分别为11.95%、88.05%、0%。两组间基因型频率分布差异无统计学意义(χ2=1.19,P>0.05)。结论 HLA-G*0105 N多态性与新疆哈族食管癌遗传易感性无相关性。
Objective To investigate the relationship between the genetic polymorphism of human leukocyte antigen G (HLA-G) * 0105N (rs 41557518) and the genetic susceptibility to esophageal cancer in Xinjiang Kazak (Kazakh) population. Methods A case-control study was conducted to investigate the association of HLA-G * 0105 N polymorphism (rs 41557518) with PCR-RFLP in 132 cases of Kazakh esophageal cancer patients in Xinjiang and 254 healthy controls (control group) Sex. Results The frequencies of genotypes C / -, C / C -, / - in the case group were 8.33%, 91.67% and 0%, respectively. The frequencies in the control group were 11.95%, 88.05% and 0% respectively. There was no significant difference in genotype distribution between the two groups (χ2 = 1.19, P> 0.05). Conclusion There is no correlation between HLA-G * 0105N polymorphism and susceptibility to Kazakh esophageal cancer in Xinjiang.