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目的提高临床医生对Churg-Srauss综合征(CSS)的认识。方法分析5例经病理学确诊CSS患者的临床特点,并复习相关文献。结果5例CSS患者均有不同病程的哮喘表现,3例有鼻炎或鼻窦炎,心脏受累和胃肠道受累各1例。5例患者外周血嗜酸粒细胞比例>10%。胸部影像学检查5例均表现肺部实变影,3例肺部实变影多变。所有病例经糖皮质激素或联合免疫抑制剂治疗后均缓解。结论哮喘、外周血嗜酸粒细胞增多和肺部实变影多变是CSS的临床特点,糖皮质激素和免疫抑制剂是主要治疗药物。
Objective To improve clinicians’ understanding of Churg-Srauss Syndrome (CSS). Methods The clinical features of 5 patients with pathologically diagnosed CSS were analyzed, and relevant literature was reviewed. Results All 5 CSS patients had asthma manifestations of different course, 3 patients had rhinitis or sinusitis, 1 heart involvement and 1 gastrointestinal tract involvement. 5 patients with peripheral blood eosinophils than 10%. Chest imaging findings in 5 cases showed consolidation of the lungs, 3 cases of varying degrees of consolidation of the lungs. All cases were relieved after glucocorticoid or combined immunosuppressive therapy. Conclusion The clinical features of asthma, peripheral blood eosinophilia and pulmonary consolidation are the clinical features of CSS. Glucocorticoid and immunosuppressive agents are the main therapeutic drugs.