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目的:探讨老年急性脑梗死患者检测血清C反应蛋白(CRP)、纤维蛋白原(FG)及脂蛋白(a)(LP(a))的变化及意义。方法:选择2013年12月-2014年12月在我院就诊的年龄≥60岁的急性脑梗死患者90例作为实验组,根据中国脑卒中患者临床神经功能缺损程度评分标准(NDS),分为轻型、中型和重型;根据病灶直径及Adama分型法分为腔隙性脑梗死、小梗死和大梗死,另外选择90例健康老人为对照组。测定所有受试者血清中的CRP、FG及LP(a)的水平,并比较它们在实验组与对照组、实验组不同严重程度和不同病变类型的患者中的差异。结果:实验组血清CRP、FG和LP(a)的水平高于对照组,且差异具有统计学意义(P<0.05);重型患者血清CRP、FG和LP(a)水平明显高于中型患者,中型患者显著高于轻型患者,且差异均有统计学意义(P<0.05);大梗死患者血清CRP、FG和LP(a)水平明显高于小梗死患者,小梗死患者显著高于腔隙性梗死患者,且差异均有统计意义(P<0.05)。结论:血清CRP、FG和LP(a)水平异常升高与老年急性脑梗死的发生发展密切相关。
Objective: To investigate the changes of serum C-reactive protein (CRP), fibrinogen (FG) and lipoprotein (a) (LP (a)) in elderly patients with acute cerebral infarction. Methods: Ninety patients with acute cerebral infarction aged ≥ 60 years who were treated in our hospital from December 2013 to December 2014 were selected as the experimental group. According to the clinical neurological deficit score (NDS) of stroke patients in China, the patients were divided into Light, medium and heavy; according to the lesion diameter and Adama classification is divided into lacunar infarction, small infarction and large infarction, the other 90 healthy elderly as the control group. The levels of CRP, FG and LP (a) in all subjects’ sera were measured and their differences between the experimental group and the control group, experimental groups of different severity and different types of lesions were compared. Results: Serum levels of CRP, FG and LP (a) in the experimental group were significantly higher than those in the control group (P <0.05). Serum levels of CRP, FG and LP (a) (P <0.05). The levels of serum CRP, FG and LP (a) in patients with severe infarction were significantly higher than those in patients with small infarction, and those in patients with small infarcts were significantly higher than those in patients with mild infarct The infarction patients, and the differences were statistically significant (P <0.05). Conclusion: The abnormally elevated serum levels of CRP, FG and LP (a) are closely related to the occurrence and development of acute cerebral infarction in the elderly.