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给 CBA 小鼠注射牛型布氏菌19后,感染的慢性化是与许与多因素有关的,本文提出了这方面的论证,这些因素是:(1)牛型布氏菌对巨噬细胞杀菌作用的相对抵抗力,使某些细菌在感染后14天的吞噬高峰中存活下来;(2)此后,巨噬细胞活性下降(这种下降一部分原因是由于刺激杀菌活性的细菌数减少,同时与本次研究中未能阐明的某种特殊的有效抑制因素的作用有关);(3)有抵抗力的布氏菌对已活化的巨噬细胞的不敏感性。这不是由于对遗传上有抵抗力的细菌的自然选择,而可能是它们在“无杀菌力”的巨噬细胞内或在巨噬细胞外完全不受侵犯之故.
After CBA injection of B. bovis 19, the chronicity of the infection is related to many factors, and this article puts forward the following arguments: (1) Effect of Bovine Escherichia coli on macrophages The relative resistance to bactericidal action allowed some bacteria to survive the peak of phagocytosis at 14 days after infection; (2) thereafter, the macrophage activity was decreased (in part due to a decrease in the number of bacteria that stimulate bactericidal activity, Related to the role of a specific and potent inhibitory factor not elucidated in this study); and (3) insensitivity of resistant Brucella to activated macrophages. This is not due to the natural selection of genetically resistant bacteria, but probably because they are completely invulnerable within the “bactericidal” macrophages or outside macrophages.