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2 回阳救逆药理研究 2.1 附子 2.1.1 抗休克作用 药理实验表明附子能使麻醉药引起的休克犬和猫的心肌收缩力增强,心输出量增加、血压回升,也能延长内毒素休克猫及烫伤休克大鼠的存活时间,显示了附子抗多种休克的功效。无论是静脉注射,还是动脉内注射附子都能扩张麻醉犬的血管,降低血管阻力,增加血流量(包括冠脉阻力和血流量),缓解烫伤大鼠肠系膜动脉收缩及微血流流态的恶化,对抗烫伤后循环血流中的血小板聚集。去甲乌药碱是其抗休克活性成分之一。 2.1.2 抗缺氧作用 我们给小鼠灌服黑顺片水煎剂10g/kg和20g/kg,发现能延长断头小鼠张口动作持续时间和氰化钾(KCN)中毒小鼠存活时间,不延长亚硝酸钠(NaNO_2)中毒和常压密闭缺氧小鼠的存活
2 Pharmacological research on resuscitation of Astragalus sinensis 2.1 Aconite 2.1.1 Pharmacological experiments on anti-shock effects show that Aconite can increase the myocardial contractility of dogs and cats caused by anesthetic drugs, increase cardiac output, increase blood pressure, and prolong the endotoxin shock. And the survival time of scald shock rats showed the efficacy of aconite against multiple shocks. Both IV and intraarterial injection of aconite can dilate blood vessels in anesthetized dogs, reduce vascular resistance, increase blood flow (including coronary resistance and blood flow), and relieve contraction of mesenteric arteries and deterioration of micro-blood flow patterns in scald rats. , counteracts platelet aggregation in the circulating blood stream after burns. Atropine is one of its anti-shock active ingredients. 2.1.2 Anti-hypoxic effect We fed mice with 10g/kg and 20g/kg blackshun decoction and found that it can prolong the duration of mouth opening and the survival time of potassium cyanide (KCN) poisoning mice. , does not prolong the survival of sodium nitrite (NaNO2) poisoning and normobaric hypoxia mice