自Owen于1945年首先报道了在胚胎期接触同种异型抗原所致免疫耐受的现象,在此基础上1953年Medawar提出胎儿作为异体抗原的载体,为何能在母体子宫内存在、发育而不被排斥,免疫学界虽已经从多方面对免疫耐受机理进行研究,已取得很大进展,但至今妊娠期间诱导产生免疫耐受的详细机制尚未阐明。究竟妊娠的免疫耐受机制如何,笔者对 Since Owen first reported in 1945 the phenomenon of immune tolerance induced by exposure to alloantigen during embryogenesis, on the basis of which Medawar proposed in 1953 that the fetus as a carrier for alloantigens can exist and develop in the mother’s uterus To be excluded, immunology circles have made great strides in researching the mechanisms of immune tolerance from many aspects. However, the detailed mechanism of induction of immune tolerance so far during pregnancy has not been elucidated yet. After all, how the immune tolerance mechanism of pregnancy, I right