重度慢性心力衰竭(SCHF)患者长期口服哌唑嗪疗程中和停药后,连续测定血流动力学参数和肾素活性的变化。分析口服螺旋内酯对哌唑嗪效应的影响,以探讨肾素-血管紧张素系统对α-肾上腺素能受体阻滞剂长期治疗过程中出现耐药性所起的作用。方法:本组27(男17、女10)例 SCHF 患者,平均年龄64(44～81)岁,包括缺血性心脏病和原发性扩张性心肌病各13例及二尖瓣置换术后1例,左室喷血分数均低于30%。试验前2周起直到试验结束,摄盐量(2g/day),狄戈辛和利尿剂剂量保持不 Long-term oral prazosin treatment in patients with severe chronic heart failure (SCHF) during and after discontinuation of the continuous determination of hemodynamic parameters and changes in renin activity. The effect of oral spironolactone on the effect of prazosin was analyzed in order to investigate the role of renin-angiotensin system in the development of drug resistance in the long-term treatment of α-adrenergic blockers. METHODS: A total of 27 SCHF patients (17 males and 10 females) with an average age of 64 (44 to 81) years, including 13 with ischemic heart disease and primary dilated cardiomyopathy, and 13 patients with mitral valve replacement 1 case, left ventricular ejection fraction were less than 30%. Two weeks before the test until the end of the test, salt intake (2g / day), dioxin and diuretic dose remained unchanged