在乳腺癌的发生、发展中,雌激素可以促进乳腺癌的形成、乳腺癌细胞的增殖、细胞周期转化和抑制细胞凋亡以及抗氧化作用,其信号转导机制涉及的通路,主要包括雌激素受体基因信号转导通路和雌激素受体非基因信号转导通路。生长因子受体介导的信号转导通路与雌激素受体基因信号转导通路之间存在交互作用,参与调控乳腺癌的演进。 In the occurrence and development of breast cancer, estrogen can promote the formation of breast cancer, breast cancer cell proliferation, cell cycle transformation and inhibition of apoptosis and anti-oxidation, signaling pathways involved in the pathway, including estrogen Receptor gene signal transduction pathway and estrogen receptor non-gene signal transduction pathway. The interaction between growth factor receptor-mediated signal transduction pathway and estrogen receptor gene signal transduction pathway is involved in the regulation of breast cancer progression.