J.Am.Chem.Soc.2014,136,2280~2283在生物体系中进行的生物相容的成键与断键反应有助于在分子水平研究生物体系.由于生物体系富含氨基酸、核苷酸、糖、核酸、蛋白质等多种生物分子,生物相容的反应需要在中性水溶液中进行,并且需要具有优秀的化学选择性与生物分子的多样反应性官能团相容.中国科学院上海有机化学研究所生命有机化学国家重点实验室的陈以昀课题组近期发展了可见光引发的生物大分子相容的脱硼炔基化反应.硼酸能在中性水溶液中稳定存在,其较小的 J. Am. Chem. Soc. 2014, 136, 2280-2283 Biocompatible bonding and cleavage reactions in biological systems facilitate the study of biological systems at the molecular level.Because the biological system is rich in amino acids, nucleosides Acids, sugars, nucleic acids, proteins and other biological molecules, biocompatible reactions need to be carried out in a neutral aqueous solution, and need to have excellent chemical selectivity and biological molecules with a variety of reactive functional groups compatible. Shanghai Chinese Academy of Organic Chemistry Chen Yi-Yun, State Key Laboratory of Applied Organic Chemistry, Institute of Life Sciences, recently developed a visible-initiated biomolecule-compatible deboronated alkynylation reaction. Boric acid can stably exist in neutral aqueous solutions. The smaller