论文部分内容阅读
目的 探讨胃癌转移、预后与肿瘤血管生成的关系。方法 用免疫组织化学过氧化酶标记的链霉卵白素染色法 (SP法 )检测 5 9例胃癌手术标本肿瘤组织微血管密度 (MVD)。结果胃癌中MVD值为 42 .7± 2 4.8,中位值为 3 6。MVD值与淋巴结转移、脉管侵犯呈正相关 (P =0 .0 168,P =0 .0 176) ;MVD值升高 (MVD≥ 3 6)与预后不良显著相关 (P =0 .0 2 14 ) 结论 胃癌MVD的检测有助于对肿瘤转移潜能的判断及评估预后。
Objective To investigate the relationship between gastric cancer metastasis, prognosis and tumor angiogenesis. Methods The microvessel density (MVD) in 59 gastric cancer specimens was detected by immunohistochemical peroxidase-labeled streptavidin staining (SP method). Results MVD in gastric cancer was 42.7 ± 2 4.8 and the median was 36. MVD was positively correlated with lymph node metastasis and vascular invasion (P = 0.016, P = 0.176); MVD (MVD≥36) was significantly associated with poor prognosis (P = 0.022 ) Conclusion The detection of MVD in gastric cancer is helpful to judge the metastatic potential of tumor and evaluate the prognosis.