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采用免疫组化方法对32例胃癌及相应的癌旁组织同时进行P21~(WAFI)蛋白的检测,结合胃癌发生的年龄、病理类型及分级与预后作了探讨。结果表明:①32例胃癌标本中阳性染色11例,弱阳性7例,阴性14例。癌旁组织中,阳性染色24例,弱阳性7例,阴性1例。两者之间的阳性率存在显著性差异(P<0.01)。②P21蛋白表达与胃癌的分级有关,分化较好的Ⅰ级与分化差的Ⅱ级之间存在显著性差异(P<0.01)。③P21蛋白表达与患者年龄、组织病理类型无明显相关(P>0.05)。结论:P21高表达与胃癌的分化程度密切相关,检测P21有无过高表达对胃癌的予后判断有一定意义。
Immunohistochemistry was used to detect P21~(WAFI) protein in 32 cases of gastric cancer and corresponding adjacent tissues, and to explore the age, pathological type, grade and prognosis of gastric cancer. The results showed that there were 11 cases of positive staining, 132 cases of weak positive and 14 cases of negative in 132 cases of gastric cancer. In the adjacent tissues, 24 cases were positively stained, 7 cases were weakly positive, and 1 was negative. There was a significant difference in the positive rate between the two (P<0.01). The expression of 2P21 protein was related to the grade of gastric cancer. There was a significant difference between the well-differentiated grade I and poorly-differentiated grade II (P<0.01). There was no significant correlation between the expression of 3P21 protein and the patient’s age and histopathological type (P>0.05). Conclusion: The high expression of P21 is closely related to the degree of differentiation of gastric cancer. The detection of whether P21 is overexpressed has certain significance for the post-judgment of gastric cancer.