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5. Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine, Acetyle

Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine, Acetyle

来源 :高等学校化学研究（英文版） | 被引量 : 0次 | 上传用户：zhangshihua11

【摘 要】

：

An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate

【作 者】

：

WU Ping XIA Er-yan SUN Jing YA 

【机 构】

：

Department of Biochemical Engineering,College of Chemistry & Chemical Engineering

【出 处】

：

高等学校化学研究（英文版）

【发表日期】

：

2004年期

【关键词】

：

1 4-Dihydropyridine β-Enamino ester Domino reaction Four-component reaction 

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论文部分内容阅读

An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation ofβ-enamino ester and its sequential Michael addition to arylidene acetoacetate.

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