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2-吡啶甲醛肟碘甲烷盐(2-PAM)为有效的有机磷解毒剂,本文对其药理作用作了初步的观察.证明对乌拉坦麻醉猫在接近临床用量时已能产生拟肾上腺素作用.连续应用多次后出现快速耐受现象.在应用抗肾上腺素药、利血平或切除两侧肾上腺后,2-PAM作用即减弱.C_6即使用至50毫克/公斤,亦不能阻断其作用,而5毫克/公斤的阿托品几能完全取消之.对离体及在位蟾蜍心脏也表现兴奋,此作用可部分地被C_6所阻断.2-PAM对离体豚鼠肠的兴奋作用,亦可被阿托品所取消.文内对其作用机制作了初步分析.
2-picolinaldehyde oxime iodine methane salt (2-PAM) as a effective organophosphate antidote, this article made a preliminary observation of its pharmacological effects. It was demonstrated that urazan anesthesia cats have been able to produce near-clinical dose of adrenergic effects Rapid application of repeated tolerance after phenomenon occurs in the application of anti-adrenergic drugs, reserpine or removal of the adrenal both sides, 2-PAM that is weakened .C_6 Even with 50 mg / kg, it can not be blocked And 5 mg / kg of atropine can be almost completely abolished.Exogenous and in situ toad heart also showed excitement, this effect can be partially blocked by C_6 .2-PAM guinea pig intestinal excitatory effect, Can also be canceled by atropine. The text made a preliminary analysis of its mechanism of action.