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特异性生长因子如血管内皮生长因子(VEGF)和转移生长因子(17GF-β1)的表达在大脑发育及神经退行性病变的发病机制方面具有重要意义。本实验对患有出血后脑积水(PHHC)及非出血性脑积水的早产儿脑脊液中(CSF)的VEGF和TGF-β1进行了研究。为了确定炎症细胞因子对VEGF和FGF-β1表达的影响,对脑脊液中的IL-6及IL-10浓度进行了测定。本研究包括
The expression of specific growth factors such as vascular endothelial growth factor (VEGF) and metastatic growth factor (17GF-β1) is of great importance in the development of the brain and the pathogenesis of neurodegenerative diseases. In this study, VEGF and TGF-β1 in cerebrospinal fluid (CSF) of preterm infants with hemorrhagic hydrocephalus (PHHC) and non-hemorrhagic hydrocephalus were studied. In order to determine the effect of inflammatory cytokines on the expression of VEGF and FGF-β1, the concentrations of IL-6 and IL-10 in cerebrospinal fluid were determined. This study includes