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目的苍白球在机体运动功能调节中发挥重要作用。形态学研究证实苍白球接受来自纹状体的神经降压素能纤维支配。有研究报道全身给予神经降压素类似物可诱导产生抗帕金森病效应。本研究旨在探讨苍白球神经降压素对氟哌啶醇所致的帕金森病僵直症状的影响。方法用行为学实验检测大鼠的帕金森病僵直症状,用电生理学实验方法记录苍白球神经元的自发放频率。结果双侧苍白球微量注射神经降压素可以缓解氟哌啶醇所致的帕金森病僵直症状。在氟哌啶醇条件下,微量注射神经降压素可以兴奋苍白球神经元。选择性神经降压素1型受体拮抗剂SR48692可以拮抗神经降压素所致的行为学和电生理学效应。结论上述结果提示,神经降压素的抗帕金森病作用可能与苍白球神经降压素受体的激活有关。
Objective globus pallidus plays an important role in the regulation of motor function. Morphological studies confirm that globus pallidus receives neurotensin fibers from the striatum. It has been reported that systemic administration of neurotensin analogs can induce anti-Parkinson’s disease effects. The purpose of this study was to investigate the effects of pallidolute neurotensin on haloperidol-induced Parkinson’s disease symptoms. Methods The behavioral experiments were used to detect the symptoms of Parkinson’s disease in rats. The electrophysiology was used to record the frequency of self-release of the globus pallidus neurons. Results Microinjection of neurotensin into bilateral globus pallidus could relieve the symptoms of haloperidol-induced Parkinson’s disease. In the haloperidol condition, microinjection of neurotensin can excite the globus pallidus neurons. The selective neurotensin type 1 receptor antagonist SR48692 antagonizes neurotensin-induced behavioral and electrophysiological effects. Conclusion The above results suggest that the anti-Parkinson’s disease effect of neurotensin might be related to the activation of globus pallidum neurotensin receptor.