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简述了无细胞百日咳菌苗毒性试验参考苗的研制现状，以及用于无细胞百日咳组分新菌苗体内生物学活性的毒性试验质控中所起的重要作用。
The current situation of research on the reference seedlings of acellular pertussis vaccine toxicity test and the important role in the quality control of toxicity test for the in vivo biological activity of the new vaccine against acellular pertussis were summarized.