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目的:分析妇科再造丸联合甲基睾丸素片治疗子宫肌瘤的临床疗效和安全性。方法:62例子宫肌瘤患者随机分为治疗组和对照组,治疗组共32人,接受妇科再和联合甲基睾丸素片联合治疗,对照组共30人,单纯接受甲基睾丸素片治疗;免疫组织化学法检测治疗组和对照组患者子宫肌瘤PR表达水平;RT-PCR检测治疗组和对照组患者子宫肌瘤Caspase-3 mRNA和PRmRNA表达;BC-5500血球分析仪检测HB、RBC、HCT,分析比较两组患者上述指标的差异。结果:治疗组临床疗效有效率为87.5%,对照组临床疗效有效率为53.3%,两组比较有统计学差异(P<0.05)。两组在治疗后HB、RBC、HCT均较治疗前改善,且治疗组较对照组改善明显,差异有统计学意义(P<0.01)。治疗组和对照组治疗后PRmRNA的表达程度与治疗前相比,明显下降,具有统计学意义(P<0.05);治疗组治疗后PRmRNA表达水平与对照组治疗后PRmRNA表达水平相比,有明显差异,具有统计学意义(P<0.05);治疗组治疗后Caspase-3mRNA的表达程度与治疗前相比,明显增强,具有统计学意义(P<0.05);治疗组治疗后Caspase-3mRNA表达水平与对照组治疗后Caspase-3mRNA表达水平相比,有明显差异(P<0.05);治疗组和对照组治疗后PR的阳性细胞数目与治疗前相比,显著下降(P<0.001);治疗组治疗后PR阳性细胞数目与对照组治疗后PR阳性细胞数目相比,有明显差异(P<0.05)。结论:妇科再造丸联合甲基睾丸素片优于单独应用甲基睾丸素片治疗子宫肌瘤。
Objective: To analyze the clinical curative effect and safety of gynecological reconstituted pill combined with methyltestosterone tablet in the treatment of uterine fibroids. Methods: 62 cases of uterine fibroids were randomly divided into treatment group and control group, the treatment group a total of 32 patients received gynecology and combined with methyl testosterone tablets, a control group of 30 patients were treated with methyl testosterone alone Immunohistochemistry was used to detect the expression of PR in uterine fibroids of the treated and control groups; Caspase-3 mRNA and PR mRNA were detected by RT-PCR in the uterine leiomyoma of the treated and control groups; HB-RBC , HCT, analysis and comparison of the two groups of patients the above indicators differences. Results: The effective rate of clinical curative effect in treatment group was 87.5%, while that in control group was 53.3%. There was significant difference between the two groups (P <0.05). The HB, RBC and HCT in both groups improved after treatment, and the treatment group improved significantly compared with the control group, the difference was statistically significant (P <0.01). The expression of PR mRNA in treatment group and control group decreased significantly compared with that before treatment (P <0.05). Compared with control group, PR mRNA expression level in treatment group and control group was significantly lower than that in control group (P <0.05). The expression level of Caspase-3 mRNA in the treatment group was significantly higher than that before treatment (P <0.05), and the expression level of Caspase-3 mRNA in the treatment group after treatment Compared with the control group, the expression of Caspase-3 mRNA was significantly different (P <0.05). The number of PR positive cells in treatment group and control group after treatment was significantly lower than that before treatment (P <0.001) The number of PR positive cells after treatment was significantly different from the number of PR positive cells after treatment (P <0.05). Conclusion: Gynecological reconstituted pill combined with methyltestosterone tablets is superior to methyltestosterone tablets alone in the treatment of uterine fibroids.