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目的:探讨PAI-A基因4G/5G多态性跟中国地区原因不明习惯性流产的关系。方法:采用Stata10.0对所有纳入结果进行异质性检验,敏感分析,影响分析和发表偏移检验。结果:6篇文章共540名病例和672名对照纳入研究。敏感性分析之后,4G/5G多态性跟习惯性流产明显相关(显性模型OR=1.934,95%CI=1.355-2.760,隐性模型OR=1.657,95%CI=1.142-2.405),共显性模型OR=1.604,95%CI=1.309-1.965)。结论:PAI-1基因4G/5G可能与中国地区原因不明习惯性流产有关。但仍然需要更多的实验证实。
Objective: To investigate the relationship between 4G / 5G polymorphism of PAI-A gene and unexplained habitual abortion in China. Methods: All included results were tested for heterogeneity, sensitivity analysis, impact analysis and publication bias test using Stata10.0. Results: A total of 540 cases and 672 controls were included in the 6 articles. After sensitivity analysis, 4G / 5G polymorphism was significantly associated with habitual abortion (dominant model OR = 1.934, 95% CI = 1.355-2.760, recessive model OR = 1.657, 95% CI = 1.142-2.405) Dominant model OR = 1.604, 95% CI = 1.309-1.965). Conclusion: PAI-1 gene 4G / 5G may be related to unexplained habitual abortion in China. But still need more experiments confirmed.