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目的:探讨喉鳞状细胞癌(LSCC)组织中BUB1蛋白的表达及临床意义。方法:采用免疫组织化学EliVision二步法检测55例LSCC组织和30例癌旁正常黏膜组织中BUB1蛋白的表达,并分析其与LSCC临床病理特征的关系。结果:BUB1蛋白在LSCC组织中的阳性表达率为50.9%(28/55),低于癌旁正常黏膜组织83.3%(25/30),两者比较差异有统计学意义(P<0.01);BUB1蛋白的表达与LSCC分化程度及淋巴结转移有相关性(均P<0.05),而与患者性别、年龄、吸烟、肿瘤原发部位、T分期及临床分期无相关性(均P>0.05)。结论:BUB1蛋白的低表达与LSCC的发生、发展有关,BUB1可能作为预测LSCC转移及预后的生物学指标之一。
Objective: To investigate the expression of BUB1 protein in laryngeal squamous cell carcinoma (LSCC) and its clinical significance. Methods: The immunohistochemical EliVision two-step method was used to detect the expression of BUB1 protein in 55 LSCC tissues and 30 adjacent normal mucosa tissues. The relationship between the expression of BUB1 protein and clinicopathological features of LSCC was analyzed. Results: The positive expression rate of BUB1 protein in LSCC was 50.9% (28/55), which was lower than that in normal mucosa (83.3%, 25/30). The difference was statistically significant (P <0.01). There was no correlation between the expression of BUB1 protein and the degree of LSCC differentiation and lymph node metastasis (all P <0.05), but not with gender, age, smoking, primary tumor site, T stage and clinical stage (all P> 0.05). Conclusion: The low expression of BUB1 protein is related to the occurrence and development of LSCC. BUB1 may be one of the biological indicators for predicting the metastasis and prognosis of LSCC.