Since 1992,assisted reproductive technology(ART)has been reported as a viable means of helping HIV-1 serodiscordant couples achieve pregnancy while theoretically reducing the risk for viral transmission.While the sum of the evidence suggests that ART is effective and safe,numerous controversies still exist.The follow-ing review addresses several of the important issues involved in the use of ART for HIV-serodiscordant couples,including patient selection,semen processing techniques,post-process HIV testing,the use of IUI vs IVF-ICSI. Since 1992, assisted reproductive technology (ART) has been reported as a viable means of helping HIV-1 serodiscordant couples achieve pregnancy while theoretically reducing the risk for viral transmission. Whilst the sum of the evidence suggests that ART is effective and safe, numerous controversies still exist. The follow-ing review addresses several of the important issues involved in the use of ART for HIV-serodiscordant couples, including patient selection, semen processing techniques, post-process HIV testing, the use of IUI vs IVF-ICSI.