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本文研究吗啉(morpholine,M)、2-巯基苯并噻唑(2-mercaptobenzothiazole,MBT)及其两种衍生物4,4’-二硫双吗啉(4,4-dithiodimorpholine,DTDM)及吗啉代巯基苯并噻唑(morpholinylmercaptobenzothiazole,MMBT)在豚鼠上的致敏力,5％及10％DTDM、MMBT及MBT可致刺激反应,M则否。用5％浓度作诱导试验,2％、0.5％及0.1％作激发试验。DTDM及MMBT组激发试验均阳性,其强度前者明显大于后者。MBT组70％阳性。M组均阴性。交叉敏感试验中DTDM组60％对MMBT发生反应,30％对M反应;MMBT组80％对MBT及20％对M发生反应;MBT组30％对MMBT出现反应。致敏潜力依次为DTDM、MMBT及MBT。二硫键、一硫键及硫氢基在本组化学物致敏中似发挥一定作用。
In this paper, morpholine (M), 2-mercaptobenzothiazole (MBT) and its two derivatives, 4,4’-dithiodimorpholine (DTDM) Sensitization of morpholinylmercaptobenzothiazole (MMBT) in guinea pigs, 5% and 10% DTDM, MMBT and MBT can cause irritation, M is not. 5% concentration for the induction test, 2%, 0.5% and 0.1% for the excitation test. DTDM and MMBT group were positive test, its intensity was significantly greater than the latter. 70% positive in MBT group. M group were negative. In cross-sensitivity test, 60% of DTDM group reacted with MMBT and 30% reacted with M; 80% of MMBT group reacted with MBT and 20% of M; 30% of MBT group reacted with MMBT. The potential of sensitization were DTDM, MMBT and MBT. Disulfide bonds, a sulfur bond and sulfhydryl groups in the chemical sensitization may play a role.