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本实验研究是作者在橡胶业职业性皮肤病调查研究基础上进行的。鉴于 IPPD 在国内橡胶业已较广泛使用.近年米,本品已小批生产,但其毒性资料缺乏,为此,进行了该项动物实验研究。急性毒性试验结果小白鼠和大白鼠经腹腔注入 IPPD 其 LD_(50)分别为475.6mg/kg,95%可信限为365.0～619.6mg/kg,239.1mg/kg。95%可信限为201.1～284.3mg/kg。本品属低毒物质。IPPD 粉剂
This experimental study is carried out by the author on the basis of a survey of occupational dermatoses in the rubber industry. In view of IPPD in the domestic rubber industry has been more widely used in recent years, the product has been small batch production, but the lack of toxicity information, for this reason, the animal experiments. The results of acute toxicity test showed that the LD50 of IPPD in mice and rats were 475.6mg / kg and 95%, respectively. The 95% confidence limits were 365.0 ~ 619.6mg / kg and 239.1mg / kg respectively. The 95% confidence limit was 201.1 to 284.3 mg / kg. This product is low toxic substances. IPPD powder