Objective To evaluate the impact of run-off vessels number on the outcomes of Supera stent (Abbott Vascular,Santa Clara,Calif,USA) for treatment of femoropopliteal occlusive disease.Methods We retrospectively evaluated the medical records of 188 consecutive patients (mean age 68.2 ± 9.6 years,100 males) undergone angiography and woven mesh stent implantation in femoral or popliteal arteries or both arterial segments,in our institution between January 1 2014 and January 1 2018.Target lesion revascularization and major adverse limb events at 12-month were evaluated comparing patients with 1-,2-or 3-run-offvessels in the foot.Results Interventional success was achieved in 100％.Stent implantation involved in the femoral site in 56 patients (30.3％),the femoropopliteal in 92 patients (48.9％) and the popliteal site in 40 patients (21.3％).A significant improvement of ankle-brachial index (0.29 ± 0.6 vs.0.88 ± 0.3,P ＜ 0.001) and Rutherford class (5.3 ± 0.8 vs.0.7 ± 1.9,P ＜ 0.01) were observed before discharge.The median follow-up duration was 12.3 months (inter quartile range:11.0 to 13.9).During the follow-up period,52 patients (27.6％) had clinical events.Primary patency at 12 months was 72.4％.The primary patency significantly increased when the runoff status.Comparing the number of events among patients with different number of run-off vessels,a significant difference (P ＜ 0.001) was observed for patients having one (24.0％) and two run-off vessels (15.0％).Conclusions The outcomes of Supera stent in femoropopliteal occlusive disease depend strictly on the number of run-off vessels.