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目的:探讨不同体质指数(BMI)的原发性高血压患者血清抵抗素(Res)水平的变化以及与颈动脉内膜中层厚度(IMT)的相关关系。方法:51例原发性高血压患者按BMI分为:肥胖组(BMI≥24,A组,23例)与非肥胖组(BMI<24,B组,28例),另选26例体检正常者作为对照组(C组),采用酶联免疫吸附法检测空腹血清Res水平;同时检测血脂、血压、身高、体重,计算BMI;采用彩色超声诊断仪测定IMT。结果:与C组空腹血清Res水平[(20.92±1.42)μg/L]相比,A组[(24.26±1.98)μg/L]和B组[(22.03±2.15)μg/L]明显升高,分别为P<0.01和P<0.05;A组与B组比较,Res水平差异有统计学意义(P<0.01);A组和B组Res均与收缩压(r=0.554,P<0.05;r=0.411,P<0.05)、TG(r=0.453,P<0.05;r=0.482,P<0.05)正相关,A组Res还与BMI(r=0.390,P<0.05)正相关,C组Res与收缩压(r=0.397,P<0.05)正相关。A组IMT[(1.17±0.48)mm]显著高于B组[(0.94±0.55)mm]和C组[(0.85±0.42)mm],均P<0.05;IMT与Res、年龄正相关。结论:Res与IMT、高血压、肥胖正相关,在动脉粥样硬化的发生和发展中起重要作用。
Objective: To investigate the changes of serum resistin (Res) in patients with essential hypertension with different body mass index (BMI) and its relationship with carotid intima-media thickness (IMT). Methods: According to BMI, 51 cases of essential hypertension were divided into obesity group (BMI≥24, A group, 23 cases) and non-obese group (BMI <24, B group, 28 cases) As control group (group C). The level of fasting serum Res was measured by enzyme-linked immunosorbent assay (ELISA). Serum lipids, blood pressure, height and body weight were measured at the same time, and BMI was calculated. IMT was measured by color sonography. Results: Compared with the fasting serum Res level [(20.92 ± 1.42) μg / L] in group A, [(24.26 ± 1.98) μg / L in group A and [22.03 ± 2.15 μg / L] in group B were significantly higher than those in group C (P <0.01 and P <0.05, respectively). There was a significant difference in Res levels between group A and group B (P <0.01) (r = 0.411, P <0.05), TG (r = 0.453, P <0.05; r = 0.482, P <0.05). The Res of group A was also positively correlated with BMI Res was positively correlated with systolic blood pressure (r = 0.397, P <0.05). IMT in group A was significantly higher than that in group B [(0.94 ± 0.55) mm] and group C [(0.85 ± 0.42) mm, P <0.05 respectively; IMT was positively correlated with Res and age. Conclusion: Res is positively correlated with IMT, hypertension and obesity, and plays an important role in the development of atherosclerosis.