c-myc的表达产物c-Myc可诱导细胞凋 亡。c-Myc诱导的细胞凋亡发生在细胞周期的不同时期,并与细胞的种类、细胞的生长条件以及引起c-Myc不当表达的原因等相关。c-Myc起介导凋亡的作用,可能主要影响凋亡的起动。c-Myc先和Max结合形成异二聚体Myc-Max,再经Myc-Max和DNA结合控制诱导凋亡所需要的转录而对凋亡进行调控。c-Myc诱导凋亡的方式有“矛盾模型”和“双重信号模型”。另外,还受p53和ROS等的影响。 c-Myc expression product c-Myc can induce apoptosis. C-Myc-induced apoptosis occurs at different stages of the cell cycle and is related to the type of cell, the growth conditions of the cell, the cause of inappropriate c-Myc expression, and the like. The role of c-Myc in mediating apoptosis may mainly affect the initiation of apoptosis. Myc-Max, a heterodimer, was first bound to Max by c-Myc. Then Myc-Max and DNA bind to control the transcription required to induce apoptosis and regulate apoptosis. The way c-Myc induces apoptosis is “paradoxical model” and “dual signal model.” In addition, also affected by p53 and ROS.