本实验研究主要是应用Parbtani方法,测定慢性肾炎肾病型(以下简称肾炎)和原发性肾小球肾病(以下简称肾病)病人,以及健康人血小板内及血浆中5—轻色胺(5 HT)浓度,结果表明:肾炎组血小板内5 HT浓度明显减低,血浆中5 HT浓度明显升高,肾病组及健康对照组间均存在显著差异。以上结果说明:慢性肾炎肾病型病人体内的血小板被激活了,可能与其肾小球内的持续性免疫损伤或循环中存在着某种引起血小板激活的物质有关。 In this study, Parbtani method was used to determine the levels of 5-HT (5 HT in patients with chronic nephritic nephropathy (hereinafter referred to as nephritis) and primary glomerulonephritis (hereinafter referred to as nephropathy) ) Concentration. The results showed that the concentration of 5 HT in the platelets of nephritis group was significantly decreased, while the concentration of 5 HT in plasma was significantly increased. There was significant difference between the nephropathy group and the healthy control group. The above results show that: Platelet in patients with chronic nephritis nephropathy is activated, may be associated with persistent immune damage in the glomeruli or circulation of some substances that cause platelet activation.