消心痛(硝酸异山梨醇酯)是临床治疗冠心病心绞痛的常用硝酸酯类药物,使用普遍且疗效好。从2006年至今临床使用消心痛过程中遇见严重不良反应5例,其中晕厥1例、休克3例、剧烈头痛1例。现报道如下:1典型病例1·1病例1,女,60岁,主因“反复性胸闷不适1年余,加重伴心前区隐痛1天”于 Heartburn (isosorbide dinitrate) is a commonly used clinical treatment of angina pectoris nitrates drugs, the use of general and good effect. From 2006 to now, there are 5 cases of serious adverse reactions in clinical use of eclampsia, including syncope in 1 case, shock in 3 cases and severe headache in 1 case. Are reported as follows: A typical case of 1.1 cases 1, female, 60 years old, mainly due to “repeated chest discomfort more than 1 year, increased with precordial pain 1 day” in