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目的:通过低恒定运动负荷试验观测慢阻肺( C O P D)患者和正常人运动负荷时换气功能,探究 C O P D患者低运动负荷时换气功能检测的临床意义.方法:对 8 例 C O P D 患者( C O P D组)和8 名正常对照(对照组)分别用自行车功量仪行恒定运动负荷35 W 15 m in,观测氧耗量( V O2 )、二氧化碳产生量( V C O2 ),分钟通气量( V E)等气体代谢指标,并于运动负荷及负荷15 m in 时检测动脉血气.结果: C O P D 组安静时和运动负荷时 V O2 及 V C O2 与对照组比较均无明显差异. C O P D组 V E于运动负荷时明显高于对照组, P< 002. C O P D组氧当量( V E/ V O2 )和二氧化碳当量( V E/ V C O2 ),于运动负荷时明显高于对照组, P < 001,另外, C O P D 组于运动负荷时 Pa O2 有所减低, Pa C O2 呈增加趋势, Aa D O2 明显增加. C O P D 组 V D/ V T 于运动负荷时明显高于对照组, P < 002.结论: C O P D患者既使是于低运动负荷时呈相对高通气状态,其换气效率明显低于正常对照.较低负荷运动试验不失为评价 C O P D换气功能的较简便及可靠的“,”Objective: The present study was undertaken to assess the pulmonary gas exchange on lower workload exercise in patients with chronic obstructive pulmonary disease (COPD). Methods: Eight patients with COPD and 8 normal subjects were investigated by exercise test (35 W) in room air for 15 minutes, respectively. Oxygen consumption (VO 2), carbon dioxide production (VCO 2), minute ventilation (VE), and arterial blood gas were measured during exercise. Results: No difference in VO 2 and VCO 2 was present between COPD patients and normal subjects both at rest and on exercise. However, VE in COPD patients showed relatively hyperventilated than that of normal subjects during exercise, P<0.02. Accordingly, VE/VO 2 and VE/VCO 2 were much higher in COPD patients than those of normal subjects, P<0 01. Moreover, patients with COPD showed a tendency of decreasing PaO 2 and increasing PaCO 2 during exercise. A aDO 2 and VD/VT increased on exercise compared with normal subjects. Conclusion: Pulmonary gas exchange measured by lower workload exercise test might be a simple and reliable mothod to evaluate the pulmonary gas exchange efficiency in patients with COPD.