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目的探讨妊娠期糖尿病(GDM)患者外周血miR-29、miR-375的表达情况及临床意义。方法以该院2013年1月~2014年12月期间收诊的135例GDM患者为研究对象,设为研究组,并以同期糖耐量正常的孕妇作为正常组,分别检测血浆空腹胰岛素(FINS)及其外周血miR-29、miR-375的表达水平。结果 1研究组及正常组的FINS分别为(15.21±5.88)m IU/L和(27.15±11.21)m IU/L(P<0.01);2研究组外周血miR-29表达量(24.83±11.24)低于正常组(76.01±12.52)(P<0.05);3研究组外周血miR-375的表达量(66.58±21.56)显著高于正常组(22.54±8.80)(P<0.05)。结论妊娠期糖尿病患者中miR-29、miR-375的异常表达与GDM易感性有一定相关,二者在GDM的筛查诊治中的作用值得更深层次的探讨研究。
Objective To investigate the expression of miR-29 and miR-375 in peripheral blood of patients with gestational diabetes mellitus (GDM) and its clinical significance. Methods A total of 135 GDM patients admitted to our hospital between January 2013 and December 2014 were enrolled in this study. The pregnant women with normal glucose tolerance during the same period were selected as the normal group, and the levels of fasting insulin (FINS) And its peripheral blood miR-29, miR-375 expression levels. Results FINS were (15.21 ± 5.88) m IU / L and (27.15 ± 11.21) m IU / L respectively in the study group and the normal group (P <0.01). The expression of miR-29 in the study group was 24.83 ± 11.24 ) Was lower than that of the normal group (76.01 ± 12.52) (P <0.05). The expression of miR-375 in the peripheral blood of the study group (66.58 ± 21.56) was significantly higher than that of the normal group (22.54 ± 8.80) (P <0.05). Conclusion The abnormal expression of miR-29 and miR-375 in patients with gestational diabetes is related to the susceptibility to GDM. The role of both in the diagnosis and treatment of GDM deserves further exploration.