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目的 探讨持续腹腔冲洗化疗 (washingintraperitonealchemotherapy ,WIP)是否较常规腹腔化疗 (con ventionalintraperitonealchemothrapy ,CIP)更有效。 方法 将 2 9例Ⅱ期以上卵巢上皮癌患者随机分为WIP组 (14例 )和CIP组 (15例 )进行以顺铂 (70mg/m2 )腹腔化疗为主的全身化疗 (PAC方案 ) ,WIP组给予DDP(70mg/m2 )常规腹腔化疗后开始以 (DDP 17 5mg/m2 +NS 5 0 0mL)的浓度进行持续冲洗化疗 ,5 0 0mL/ 2h ,治疗总时间为 12h ;CIP组为一次性灌注DDP70mg/m2 +NS 2 0 0 0mL。以治疗前后CA12 5、腹水细胞周期及细胞凋亡率、尿 β2m来评价近期临床疗效。结果 WIP组 (CR +PR)率为 5 6 % ,CIP组 2 0 % ,P <0 0 5 ;S期在WIP组呈下降趋势 ;凋亡率在WIP组的差值 (7 6 4% )显著高于CIP组 (1 82 % ) ,P <0 0 5 ;尿 β2m在两组的变化也具有统计学意义 (P <0 0 5 )。结论 持续冲洗腹腔化疗的近期疗效优于常规腹腔化疗方法 ,可适用于临床
Objective To investigate whether continuous intraperitoneal chemotherapy (WIP) is more effective than conventional intraperitoneal chemotherapy (CIP). Methods Twenty-nine patients with epithelial ovarian cancer with stage Ⅱ or higher were randomly divided into WIP group (14 cases) and CIP group (15 cases) with cisplatin (70mg / m2) intraperitoneal chemotherapy (PAC) The patients in the CIP group were treated with continuous chemotherapy (DDP 17 5mg / m2 + NS 500mL) at a dose of 500mL / 2h after DDP (70mg / m2) Perfusion DDP 70mg / m2 + NS 200ml. Before and after treatment CA12 5, ascites cell cycle and apoptosis rate, urine β2m to evaluate the recent clinical efficacy. Results The rate of CR + PR in WIP group was 56%, in CIP group 20%, P <0 05, and in S phase in WIP group was decreasing. The difference of apoptosis rate in WIP group was 74.4% Which was significantly higher than that of CIP group (1 82%), P 0 05 and urinary β2m in both groups (P 0.05). Conclusion The continuous curative effect of intraperitoneal chemotherapy is better than that of conventional intraperitoneal chemotherapy and can be applied to clinical