目的：研究小儿过敏性紫癜结肠粘膜病理改变、临床意义及其治疗措施。方法：采用纤维结肠镜对临床确诊为过敏性紫癜患儿结肠腔内病变形态进行观察及处理。结果：过敏性紫癜患儿共９２例，通过内镜观察发现，４７例（５１１％）患儿结肠粘膜病变，镜下表现位于全结肠粘膜及粘膜下呈不同程度水肿、出血，重者粘膜糜烂和溃疡。其中腹型紫癜２４／３３例（７２７３％），单纯皮肤型紫癜８／２３例（３４７８％），关节型５／１１例（４５４５％），肾脏型２／５例（４００％），混合型８／２０例（４０．０％）。阳性病例中３例发现鞭虫。肠套叠１例经内镜气压复位，９例粘膜糜烂溃疡渗血者中５例经局部喷洒止血剂治愈。结论：小儿过敏性紫癜的结肠粘膜病变检出率高，在临床各型紫癜病例均有发生，以腹型紫癜发生率最高，采用内镜检查了解肠粘膜病变的发生及轻重程度，对指导临床治疗有重要意义 Objective: To study the pathological changes of colonic mucosa in children with allergic purpura and its clinical significance and treatment. Methods: Colonoscopy in patients with clinically diagnosed as Henoch-Schonlein purpura in children with colon cavity morphology observation and treatment. Results: A total of 92 children with Henoch-Schonlein purpura showed that colonic mucosal lesions were found in 47 cases (511%) of children with allergic purpura. The results of microscopic examination showed edema and hemorrhage in all colon mucosa and submucosa, Mucosal erosion and ulcers. There were 24/33 abdominal purpura cases (72.73%), 8/23 pure skin purpura cases (34.78%), 5/11 cases (45.45%) of joint type and 2/5 cases of kidney type 40  0%), mixed type 8/20 cases (40.0%). Three cases of whipworm were found in positive cases. Intestinal intussusception in 1 case by endoscopic pressure reduction, 9 cases of mucosal erosion ulcer bleeding in 5 cases of local spraying hemostatic cure. Conclusion: The detection rate of colonic mucosal lesions in children with Henoch-Schonlein purpura is high, and it has been found in all kinds of purpura cases in clinic. The incidence of abdominal purpura is the highest. The occurrence and severity of intestinal mucosal lesions are detected by endoscopy. Treatment is important