消化性溃疡42例,随机区组,双盲对照。治疗组服氢氧化铝凝胶加三环类抗抑郁剂(选多虑平),对照组仅服氢氧化铝凝胶。4周愈合率,治疗组为71.4％,对照组为52.4％,差异有统计学意义(P<0.05)。本文研究结果还提示,三环类抗抑郁剂疗效机理可能与降低血浆肾素活性,减轻情绪应激,减少空腹胃酸分泌有关。而情绪不稳的人格特征可能影响空腹胃酸的分泌水平。 Peptic ulcer in 42 cases, randomized block, double-blind control. The treatment group served aluminum hydroxide gel plus tricyclic antidepressants (doxepin), the control group served only with aluminum hydroxide gel. The healing rate at 4 weeks was 71.4% in the treatment group and 52.4% in the control group, with significant difference (P <0.05). The results of this study also suggest that tricyclic antidepressants may reduce the plasma renin activity, reduce emotional stress and reduce fasting gastric acid secretion. Emotional personality traits may affect the fasting gastric acid secretion.