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目的探讨抑制素A和抑制素B水平与妊娠结局的相关性。方法选取2010年5月-2014年5月在该院进行产前检查的孕11~14周孕妇为研究对象。抽取研究对象血清,应用免疫发光法检测抑制素A与抑制素B水平,随后观察妊娠结局。按照妊娠结局分为妊娠期高血压疾病43例,胎儿生长受限48例,巨大胎儿43例,自然流产40例,胎儿窘迫50例,妊娠期糖尿病45例,以上孕妇均只出现单一结局;另选取同期正常孕妇50例为对照组。分析孕早期抑制素水平与不同妊娠结局的相关性。结果妊娠期高血压疾病、胎儿生长受限孕妇孕早期血清抑制素A水平明显高于对照组,差异有统计学意义(P<0.05);而其抑制素B水平与对照组比较,差异无统计学意义(P>0.05)。巨大胎儿、自然流产、胎儿窘迫及妊娠期糖尿病孕早期抑制素水平与对照组比较,差异均无统计学意义(P均>0.05)。结论孕早期抑制素A水平升高与妊娠期高血压疾病和胎儿生长受限相关;孕早期抑制素B水平下降与妊娠期高血压疾病和胎儿生长受限无相关性。孕早期抑制素水平与巨大胎儿、自然流产、胎儿窘迫和妊娠期糖尿病均无明显相关性。
Objective To investigate the correlation between the levels of inhibin A and inhibin B and pregnancy outcome. Methods From May 2010 to May 2014, pregnant women aged 11-14 weeks pregnant during prenatal examination in this hospital were selected as the research objects. Serum samples were drawn, and the levels of inhibin A and inhibin B were measured by immunoluminescence, and then the pregnancy outcome was observed. In accordance with the pregnancy outcome is divided into 43 cases of hypertensive disorders of pregnancy, fetal growth restriction in 48 cases, 43 cases of huge fetus, spontaneous abortion in 40 cases, 50 cases of fetal distress, 45 cases of gestational diabetes mellitus, more than a single pregnancy were only a single outcome; Select the same period of 50 normal pregnant women as the control group. Analysis of early pregnancy inhibin levels and the relationship between different pregnancy outcomes. Results The levels of serum inhibin A in pregnant women with gestational hypertension and fetal growth restriction in early pregnancy were significantly higher than those in control group (P <0.05), while the statin B levels were not statistically different from those in control group Significance (P> 0.05). There were no significant differences in the levels of early inhibin in giant fetus, spontaneous abortion, fetal distress and gestational diabetes mellitus (all P> 0.05). Conclusions The elevated level of inhibin A in early pregnancy is associated with hypertensive disorder complicating pregnancy and fetal growth restriction. The decrease of inhibin B level in early pregnancy is not associated with hypertensive disorder complicating pregnancy and fetal growth restriction. Early pregnancy inhibin levels and macrosomia, spontaneous abortion, fetal distress and gestational diabetes were not significantly correlated.