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目的 :观察达克普隆对胃食管反流病 (GERD)疗效。方法 :14 5例患者分为 2组。达克普隆组 110例其中包括 2 0例雷尼替丁治疗无效者 ,另一组为雷尼替丁组 35例 ,达克普隆 30mg一日二次 ,二周后改为 30mg每日一次至第 8周 ,然后复查胃镜 ,其后给予 30mg/ qd维持治疗或症状自控治疗。雷尼替丁为 15 0mg每日 2次至第 8周复查胃镜 ,其后给予 15 0mg每晚 1次或症状自控治疗 ,两组均加用促动力药西沙必利 ,并于 2、4、8周末评价症状显效率。结果 :达克普隆治疗 2、4、8周后症状显效率为 6 2 %、86 %、93% ,8周食管炎治愈率Ⅰ级 95 8% ,Ⅱ级 81 2 % ,Ⅲ级 6 0 % ,雷尼替丁 2、4、8周后症状显效率为 5 3 3%、6 2 2 %、88% ,8周食管炎 (Ⅰ级 )治愈率 71 1%。结论 :达克普隆在GERD治疗中优于雷尼替丁 ,尤其在雷尼替丁无效患者中更显示其优越性。
Objective: To observe the effect of daclypron on gastroesophageal reflux disease (GERD). Methods: 14 5 patients were divided into two groups. Duckopron group of 110 cases, including 20 cases of ranitidine ineffective treatment, the other for the ranitidine group of 35 cases, up to 30 mg of dopronone twice a day, two weeks later changed to 30mg daily Once to the eighth week, and then review the gastroscope, followed by 30mg / qd maintenance treatment or symptoms of controlled treatment. Ranitidine for 15 0mg daily 2 to 8 weeks review gastroscopy, followed by 15 0mg per night or symptoms of self-controlled treatment, both groups were boosted with cisapride, and in 2, 4, 8 weekend evaluation symptoms were markedly efficient. Results: After 2, 4 and 8 weeks of daplon treatment, the effective rates of symptoms were 62%, 86% and 93% respectively. The cure rates of esophagitis in grade 8 were 95.8%, 81.2% and 0.60% %. The effective rates of symptoms of ranitidine after 2, 4 and 8 weeks were 53.3%, 62.2% and 88%, respectively. The cure rate of grade 8 esophagitis was 71.1%. Conclusion: Dopipron is better than ranitidine in the treatment of GERD, especially its superiority in patients with ranitidine inefficiency.