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作者用离体灌流豚鼠气管螺旋条标本,研究α-受体阻断剂酚苄明对支气管扩张剂作用的影响,结果以收缩指数(C.I.)来表示,C.I.前加“—”号表示气管扩张作用。用放射免疫方法测定气管和肺组织中 cAMP和 cGMP 含量。结果:酚苄明(100毫微克/毫升)对气管平滑肌张
The authors used perfused guinea pig tracheal spiral specimens to study the effect of the α-blocker phenoxybenzamine on bronchodilators. The results were expressed as the systolic index (CI). The “-” sign before the CI indicates tracheal dilatation effect. Radioimmunoassay was used to determine cAMP and cGMP contents in trachea and lung tissue. RESULTS: Phenoxybenzamine (100 ng / mL) had tracheal smooth muscle tension