近来发现胰腺干细胞可分化成产胰岛素细胞,从而为糖尿病治疗提供一个新的途径,但是具体哪种细胞为胰腺干细胞仍未明确。目前关注较多的有胰腺Nestin阳性细胞,但由于存在部位及数量多而存在较多争议。还有一些细胞如基底细胞、表达葡萄糖转运子2细胞等也被研究。另外有研究提示胰管细胞可能为一种功能干细胞,可以暂时分化成胰腺干细胞。目前由于缺乏唯一的标志物和可信的评价指标,要最终明确胰腺干细胞还需进一步研究。 Recently, it has been found that pancreatic stem cells can differentiate into insulin-producing cells, thus providing a new way for the treatment of diabetes. However, it is unclear which specific cells are pancreatic stem cells. At present, there are more pancreatic Nestin positive cells, but there are more controversies due to the existence of sites and quantity. Still other cells such as basal cells, glucose transporter 2 cells, etc. have also been studied. Another study suggests that pancreatic duct cells may be a functional stem cells that can temporarily differentiate into pancreatic stem cells. At present, due to the lack of unique markers and credible evaluation indicators, it is necessary to further study pancreatic stem cells.