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Objective To observe the effects of therapeutic ultrasound in vitro on hyperlipemia. Methods Comparing clinical effects of only ultrasound treatment, only administration of Geminifbrozip and combination of these two therapies. These patientswere divided into three groups and the follow up observation was 3 months. Result Curative effect of the ultrasound group was better than that of drug group (P< 0.05). Curative effect of the combined therapy group was the best(P< 0.01). Result of follow up suggested that serum glyceryl trioleate and cholesterol relapse rate of ultrasonic group was lower than that of drug group .Serum glyceryl trioleate and cholesterol relapse rate of combined therapy group was the lowest. Conclusion Combination of ultrasound treatment in vitro and administration of Geminifbrozip is the best way to treat hyperlipemia, and it is not easy to relapse.