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β-内酰胺类抗生素是目前临床抗感染治疗最普遍应用的一类抗生素,随着这类药物的广泛使用(特别是滥用和误用)和致病菌的变迁,产生了病原菌对药物的耐药性问题,而且耐药发生率相当高。细菌产生β-内酰胺酶(β-Iactamase)是80％病原菌耐药的原因之一,另外约12％和8％病原菌的耐药分别与细菌细胞外膜通透性障碍和靶位的改变有关。本文对细菌产生β-内酰胺酶所致的耐药性作一简要综述,以便采取相应对策以防止耐药性的蔓延。 1 β-内酰胺酶的特性 β-内酰胺酶是指能催化水解6-氨基青霉烷酸(6-APA)和7-氨基头孢烷酸(7-ACA)及其N-酰基衍生物分子中β-内酰胺环酰胺键的灭活酶。细菌产生β-内酰胺酶是细菌对β-内酰
β-lactam antibiotics is currently the most commonly used clinical anti-infective therapy of a class of antibiotics, with the widespread use of such drugs (especially abuse and misuse) and pathogenic bacteria change, resulting in the resistance of pathogens to drugs Drug problems, and the incidence of drug resistance is quite high. Bacterial production of β-lactamase (β-lactamase) is one of the causes of 80% of pathogenic bacteria, and about 12% and 8% of the pathogenic bacteria resistant to bacterial outer membrane permeability and target changes respectively . This article gives a brief overview of bacterial resistance to β-lactamase-induced resistance in order to take appropriate countermeasures to prevent the spread of resistance. 1 β-lactamase characteristics β-lactamase refers to the ability to catalyze the hydrolysis of 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA) and its N-acyl derivative molecules Β-lactam cyclic amide bond inactivated enzyme. Bacterial production The beta-lactamase is a bacterial to beta-lactam