抗癌基因是一类能够抑制细胞生长并能潜在抑制癌变作用的基因,当其失活以后,可以使癌基因充分发挥作用而导致恶性肿瘤的发生和发展。迄今为止,在已知的抗癌基因和癌基因中,P53抗癌基因突变是最常见的。1979年,在SV40转化的鼠细胞中,发现了这种能够与SV40大T抗原形成复合物的蛋白,所以早期人们认为它是肿瘤抗原。把P53基因转入鼠的胚胎成纤维细胞,它自身或与ras癌基因协同作用,使这些细胞具有不死性。只是在近几 Anti-oncogene is a kind of gene that can inhibit cell growth and potentially inhibit canceration. When it is inactivated, it can make the oncogene fully play its role and lead to the occurrence and development of malignant tumors. To date, P53 anti-oncogene mutations are the most common among known anti-oncogenes and oncogenes. In 1979, this protein was found in SV40-transformed murine cells to form a complex with the SV40 large T antigen, so early on it was thought to be a tumor antigen. The P53 gene is transferred into mouse embryonic fibroblast cells and synergizes with the ras oncogene to make these cells immortal. Just in recent days